Extracellular vesicles from parasitic helminths and their potential utility as vaccines

Mekonnen, Gebeyaw Getnet, Pearson, Mark, Loukas, Alex, and Sotillo, Javier (2018) Extracellular vesicles from parasitic helminths and their potential utility as vaccines. Expert Review of Vaccines, 17 (3). pp. 197-205.

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Abstract

Introduction: Helminths are multicellular parasites affecting nearly three billion people worldwide. To orchestrate a parasitic existence, helminths secrete different molecules, either in soluble form or contained within extracellular vesicles (EVs). EVs are secreted by most cell types and organisms, and have varied roles in intercellular communication, including immune modulation and pathogenesis.

Areas covered: In this review, we describe the nucleic acid and proteomic composition of EVs from helminths, with a focus on the protein vaccine candidates present on the EV surface membrane, and discuss the potential utility of helminth EVs and their constituent proteins in the fight against helminth infections.

Expert commentary: A significant number of proteins present in helminth-secreted EVs are known vaccine candidates. The characterization of helminth EV proteomes will shed light on host–pathogen interactions, facilitate the discovery of new diagnostic biomarkers, and provide a novel approach for the development of new control measures against helminth infections.

Item ID: 57270
Item Type: Article (Research - C1)
ISSN: 1744-8395
Keywords: helminths, extracellular vesicles, vaccine, proteins, tetraspanins
Funders: National Health and Medical Research Council (NHMRC)
Date Deposited: 04 Mar 2019 23:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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