Adaptive radiation of the flukes of the family Fasciolidae inferred from genome-wide comparisons of key species

Choi, Young-Jun, Fontenla, Santiago, Fischer, Peter U., Le, Thanh Hoa, Costabile, Alicia, Blair, David, Brindley, Paul J., Tort, Jose F., Cabada, Miguel M., and Mitreva, Makedonka (2020) Adaptive radiation of the flukes of the family Fasciolidae inferred from genome-wide comparisons of key species. Molecular Biology and Evolution, 37 (1). pp. 84-99.

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Abstract

Liver and intestinal flukes of the family Fasciolidae cause zoonotic food-borne infections that impact both agriculture and human health throughout the world. Their evolutionary history and the genetic basis underlying their phenotypic and ecological diversity are not well understood. To close that knowledge gap, we compared the whole genomes of Fasciola hepatica, Fasciola gigantica, and Fasciolopsis buski and determined that the split between Fasciolopsis and Fasciola took place similar to 90 Ma in the late Cretaceous period, and that between 65 and 50 Ma an intermediate host switch and a shift from intestinal to hepatic habitats occurred in the Fasciola lineage. The rapid climatic and ecological changes occurring during this period may have contributed to the adaptive radiation of these flukes. Expansion of cathepsins, fatty-acid-binding proteins, protein disulfide-isomerases, and molecular chaperones in the genus Fasciola highlights the significance of excretory-secretory proteins in these liver-dwelling flukes. Fasciola hepatica and Fasciola gigantica diverged similar to 5 Ma near the Miocene-Pliocene boundary that coincides with reduced faunal exchange between Africa and Eurasia. Severe decrease in the effective population size similar to 10ka in Fasciola is consistent with a founder effect associated with its recent global spread through ruminant domestication. G-protein-coupled receptors may have key roles in adaptation of physiology and behavior to new ecological niches. This study has provided novel insights about the genome evolution of these important pathogens, has generated genomic resources to enable development of improved interventions and diagnosis, and has laid a solid foundation for genomic epidemiology to trace drug resistance and to aid surveillance.

Item ID: 62503
Item Type: Article (Research - C1)
ISSN: 1537-1719
Keywords: food-borne flukes, Fasciola hepatica, Fasciola gigantica, Fasciolopsis buski, genome evolution, adaptive radiation
Copyright Information: (c) The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Funders: National Institutes of Health (NIH), USA, National Institute of Health (NIH), USA, National Institute of Allergy and Infectious Disease (NIAID), National Institute of General Medical Sciences (NIGMS)
Projects and Grants: NIH National Human Genome Research Institute award number U54HG003079, NIH NIAID AI081803, NIH NIGMS GM097435
Date Deposited: 11 Mar 2020 07:47
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060411 Population, Ecological and Evolutionary Genetics @ 20%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 50%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060309 Phylogeny and Comparative Analysis @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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