Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents

Li, Xin, Gorle, Anil K., Sundaraneedi, Madhu K., Keene, F. Richard, and Collins, J. Grant (2018) Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents. Coordination Chemistry Reviews, 375. pp. 134-147.

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Abstract

Due to the clinical success and limitations of platinum-based anticancer drugs, there has been considerable interest in the development of new therapeutic agents based upon other transition metals, in particular ruthenium. There have now been many studies demonstrating the anticancer and antimicrobial properties of kinetically-inert polypyridylruthenium(II) complexes. This review showcases the diverse range of polypyridylruthenium complexes that exhibit significant biological activity, and discusses the relationship between their chemical structure and biological processing (cellular uptake and localisation) in eukaryotic cells. Perhaps more importantly, this review also highlights several recent studies that have shown kinetically-inert polypyridylruthenium(II) complexes can exhibit anticancer activity in in vivo trials – studies that provide the "proof of concept" that this class of metal-based agent has real clinical potential.

Item ID: 52664
Item Type: Article (Research - C1)
ISSN: 1873-3840
Keywords: polypyridylruthenium(II) complexes; anticancer; antimicrobial; cellular uptake; cellular localisation, in vivo studies
Date Deposited: 25 Feb 2018 23:19
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 20%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 40%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 40%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 20%
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