Responses of neurogenesis and neuroplasticity related genes to elevated CO2 levels in the brain of three teleost species

Lai, Floriana, Fagernes, Cathrine E., Bernier, Nicholas J., Miller, Gabrielle M., Munday, Philip L., Jutfelt, Fredrik, and Nilsson, Goran E. (2017) Responses of neurogenesis and neuroplasticity related genes to elevated CO2 levels in the brain of three teleost species. Biology Letters, 13 (8).

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The continuous increase of anthropogenic CO2 in the atmosphere resulting in ocean acidification has been reported to affect brain function in some fishes. During adulthood, cell proliferation is fundamental for fish brain growth and for it to adapt in response to external stimuli, such as environmental changes. Here we report the first expression study of genes regulating neurogenesis and neuroplasticity in brains of three-spined stickleback (Gasterosteus aculeatus), cinnamon anemonefish (Amphiprion melanopus) and spiny damselfish (Acanthochromis polyacanthus) exposed to elevated CO2. The mRNA expression levels of the neurogenic differentiation factor (NeuroD) and doublecortin (DCX) were upregulated in three-spined stickleback exposed to high-CO2 compared with controls, while no changes were detected in the other species. The mRNA expression levels of the proliferating cell nuclear antigen (PCNA) and the brain-derived neurotrophic factor (BDNF) remained unaffected in the high-CO2 exposed groups compared to the control in all three species. These results indicate a species-specific regulation of genes involved in neurogenesis in response to elevated ambient CO2 levels. The higher expression of NeuroD and DCX mRNA transcripts in the brain of high-CO2-exposed three-spined stickleback, together with the lack of effects on mRNA levels in cinnamon anemonefish and spiny damselfish, indicate differences in coping mechanisms among fish in response to the predicted-future CO2 level.

Item ID: 51260
Item Type: Article (Research - C1)
ISSN: 1744-957X
Keywords: neurogenesis, three-spined stickleback, cinnamon anemonefish, spiny damselfish, elevated CO2
Funders: University of Oslo, Swedish Research Council, ARC Centre of Excellence for Coral Reef Studies, Great Barrier Reef Marine Park Authority (GBRMPA), Sea World Research and Rescue Foundation, Australian Coral Reef Society
Date Deposited: 18 Oct 2017 07:38
FoR Codes: 31 BIOLOGICAL SCIENCES > 3103 Ecology > 310305 Marine and estuarine ecology (incl. marine ichthyology) @ 50%
37 EARTH SCIENCES > 3708 Oceanography > 370802 Chemical oceanography @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
96 ENVIRONMENT > 9603 Climate and Climate Change > 960399 Climate and Climate Change not elsewhere classified @ 50%
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