Temporal genetic diversity of Schistosoma japonicum in two endemic sites in China revealed by microsatellite markers

Yin, Mingbo, Li, Hongyan, Blair, David, Xu, Bin, Feng, Zheng, and Hu, Wei (2016) Temporal genetic diversity of Schistosoma japonicum in two endemic sites in China revealed by microsatellite markers. Parasites & Vectors, 9. pp. 1-5.

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Abstract

Background: Schistosomiasis is one of the neglected tropical diseases. The causative agent of schistosomiasis in China, Schistosoma japonicum, has long been a major public health problem. An understanding of fundamental evolutionary and genetic processes in this species has major implications for its control and elimination. Intensive control efforts have greatly reduced the incidence of schistosomiasis in China, but little is known about the genetic consequences of these efforts.

Methods: To investigate this, we sampled twice (years 2003 and 2011) from two endemic regions where populations of S. japonicum had persisted despite control efforts and genotyped these samples using ten microsatellite markers. Our main hypothesis was that parasite genetic diversity would be greatly reduced across this time period.

Conclusions: There was no apparent reduction in allelic diversity, and a non-significant reduction in clonal diversity in these parasite populations between 2003 and 2011. We did, however, detect temporal genetic differentiation among the samples. Such a significant temporal genetic variation of S. japonicum populations has not been reported before.

Item ID: 47944
Item Type: Article (Refereed Research - C1)
Keywords: Schistosoma japonicum, genetic diversity, population structure, temporal variation, microsatellite
Additional Information:

© 2016 Yin et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

ISSN: 1756-3305
Funders: National Science Foundation of China (NSFC), International S&T Cooperation Program of China (ISTCPC), Technology Major Program (TMP)
Projects and Grants: NSFC No. 91431104, ISTCPC 2014DFA31130, TMP Grant No. 2012ZX10004-220, TMP Grant No. 2012ZX10004-011
Date Deposited: 28 Apr 2017 00:23
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060411 Population, Ecological and Evolutionary Genetics @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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