Sex-chromosome homomorphy in Palearctic tree frogs results from both turnovers and XY recombination

Dufresnes, Christophe, Borzée, Amaël, Horn, Agnes, Stöck, Matthias, Ostini, Massimo, Sermier, Roberto, Wassef, Josef, Litvinchuck, Spartak N., Kosch, Tiffany A., Waldman, Bruce, Jang, Yikweon, Brelsford, Alan, and Perrin, Nicholas (2015) Sex-chromosome homomorphy in Palearctic tree frogs results from both turnovers and XY recombination. Molecular Biology and Evolution, 32 (9). pp. 2328-2337.

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Abstract

Contrasting with birds and mammals, poikilothermic vertebrates often have homomorphic sex chromosomes, possibly resulting from high rates of sex-chromosome turnovers and/or occasional X-Y recombination. Strong support for the latter mechanism was provided by four species of European tree frogs, which inherited from a common ancestor (∼ 5 Ma) the same pair of homomorphic sex chromosomes (linkage group 1, LG1), harboring the candidate sex-determining gene Dmrt1. Here, we test sex linkage of LG1 across six additional species of the Eurasian Hyla radiation with divergence times ranging from 6 to 40 Ma. LG1 turns out to be sex linked in six of nine resolved cases. Mapping the patterns of sex linkage to the Hyla phylogeny reveals several transitions in sex-determination systems within the last 10 My, including one switch in heterogamety. Phylogenetic trees of DNA sequences along LG1 are consistent with occasional X-Y recombination in all species where LG1 is sex linked. These patterns argue against one of the main potential causes for turnovers, namely the accumulation of deleterious mutations on nonrecombining chromosomes. Sibship analyses show that LG1 recombination is strongly reduced in males from most species investigated, including some in which it is autosomal. Intrinsically low male recombination might facilitate the evolution of male heterogamety, and the presence of important genes from the sex-determination cascade might predispose LG1 to become a sex chromosome.

Item ID: 42976
Item Type: Article (Research - C1)
ISSN: 1537-1719
Funders: Swiss National Science Foundation (SNSF), University of Lausanne
Projects and Grants: SNSF grant no. 31003A-129894
Date Deposited: 05 Oct 2017 02:30
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060403 Developmental Genetics (incl Sex Determination) @ 60%
06 BIOLOGICAL SCIENCES > 0608 Zoology > 060809 Vertebrate Biology @ 10%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060309 Phylogeny and Comparative Analysis @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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