Use of naked DNA immunization for screening of leptospiral antigens as potential vaccinogens

Cerqueira, G., Silva, E., Seixas, F., Athanazio, D., Amaral, M., Vasconcelos, F., Hartwig, D., Ribeiro, S., and Dellagostin, O. (2009) Use of naked DNA immunization for screening of leptospiral antigens as potential vaccinogens. International Journal of Antimicrobial Agents, 34 (Supplement 2). P162. S78 - S78.

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The genomic DNA of Leptospira interrogans Canicola strain Kito was used as a template for amplification of the target sequences and vaccinogen production. Female Golden Syrian hamsters with 4 5 weeks of age were immunized according to previously described protocols: 80/40 μg (first/second immunization) or 80/40/40 μg (first/second/third immunization) for subunit vaccines and 100/100 mg for plasmid vectors. Each experimental group included 6 to 8 animals. Homologous challenge was tested by strain Kito and heterologous challenge by L. interrogans serovar Copenhageni strain Fiocruz L1-130.

Item ID: 37435
Item Type: Article (Abstract)
ISSN: 1872-7913
Additional Information:

Abstracts from the 26th International Congress of Chemotherapy and Infection, June 18-21 2009, Toronto, Canada.

Date Deposited: 19 Mar 2015 01:32
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 20%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060503 Microbial Genetics @ 20%
10 TECHNOLOGY > 1004 Medical Biotechnology > 100499 Medical Biotechnology not elsewhere classified @ 60%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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