Cerqueira, G., Silva, E., Seixas, F., Athanazio, D., Amaral, M., Vasconcelos, F., Hartwig, D., Ribeiro, S., and Dellagostin, O. (2009) Use of naked DNA immunization for screening of leptospiral antigens as potential vaccinogens. International Journal of Antimicrobial Agents, 34 (Supplement 2). P162. S78 - S78.

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Abstract

The genomic DNA of Leptospira interrogans Canicola strain Kito was used as a template for amplification of the target sequences and vaccinogen production. Female Golden Syrian hamsters with 4 5 weeks of age were immunized according to previously described protocols: 80/40 μg (first/second immunization) or 80/40/40 μg (first/second/third immunization) for subunit vaccines and 100/100 mg for plasmid vectors. Each experimental group included 6 to 8 animals. Homologous challenge was tested by strain Kito and heterologous challenge by L. interrogans serovar Copenhageni strain Fiocruz L1-130.

Item ID:	37435
Item Type:	Article (Abstract)
ISSN:	1872-7913
Additional Information:	Abstracts from the 26th International Congress of Chemotherapy and Infection, June 18-21 2009, Toronto, Canada.
Date Deposited:	19 Mar 2015 01:32
FoR Codes:	06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 20% 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060503 Microbial Genetics @ 20% 10 TECHNOLOGY > 1004 Medical Biotechnology > 100499 Medical Biotechnology not elsewhere classified @ 60%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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