Major prospects for exploring canine vector-borne diseases and novel intervention methods using 'omic technologies

Gasser, Robin B., Cantacessi, Cinzia, Campbell, Bronwyn E., Hofmann, Andreas, and Otranto, Domenico (2011) Major prospects for exploring canine vector-borne diseases and novel intervention methods using 'omic technologies. Parasites & Vectors, 4 (April). 53. pp. 1-10.

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Canine vector-borne diseases (CVBDs) are of major socioeconomic importance worldwide. Although many studies have provided insights into CVBDs, there has been limited exploration of fundamental molecular aspects of most pathogens, their vectors, pathogen-host relationships and disease and drug resistance using advanced, 'omic technologies. The aim of the present article is to take a prospective view of the impact that next-generation, 'omics technologies could have, with an emphasis on describing the principles of transcriptomic/genomic sequencing as well as bioinformatic technologies and their implications in both fundamental and applied areas of CVBD research. Tackling key biological questions employing these technologies will provide a 'systems biology' context and could lead to radically new intervention and management strategies against CVBDs.

Item ID: 26448
Item Type: Article (Research - C1)
ISSN: 1756-3305
Keywords: parasitic nematodes; bioinformatics; high-throughput sequencing; transcriptomics
Funders: Australian Research Council (ARC), National Health and Medical Research Council (NHMRC), Melbourne Water Corporation
Date Deposited: 29 Apr 2013 01:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 60%
08 INFORMATION AND COMPUTING SCIENCES > 0803 Computer Software > 080301 Bioinformatics Software @ 10%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 30%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 10%
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