Heartworm genomics: unprecedented opportunities for fundamental molecular insights and new intervention strategies
Gasser, Robin, and Cantacessi, Cinzia (2011) Heartworm genomics: unprecedented opportunities for fundamental molecular insights and new intervention strategies. Topics in Companion Animal Medicine, 26 (4). pp. 193-199.
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Abstract
Vector-borne diseases, including canine heartworm disease (CHWD), are of major socioeconomic and canine health importance worldwide. Although many studies have provided insights into CHWD, to date there has been limited study of fundamental molecular aspects of Dirofilaria immitis itself, its relationship with the canine host, its vectors, as well as the potential of drug resistance to emerge, using advanced -omic technologies. This article takes a prospective view of the benefits that advanced -omics technologies will have toward understanding D. immitis and CHWD. Tackling key biological questions using these technologies will provide a "systems biology" context and could lead to radically new intervention and management strategies against heartworm.
| Item ID: | 26433 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1876-7613 |
| Keywords: | canine heartworm disease (CHWD), Dirofilaria immitis, heartworm, drug resistance, genomics, genetics, molecular biology, transcriptomics |
| Date Deposited: | 29 Apr 2013 02:38 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30% 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 60% 08 INFORMATION AND COMPUTING SCIENCES > 0803 Computer Software > 080301 Bioinformatics Software @ 10% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60% 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 30% 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 10% |
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