Key strongylid nematodes of animals: impact of next-generation transcriptomics on systems biology and biotechnology

Cantacessi, Cinzia, Campbell, Bronwyn E., and Gasser, Robin B. (2012) Key strongylid nematodes of animals: impact of next-generation transcriptomics on systems biology and biotechnology. Biotechnology Advances, 30 (3). pp. 469-488.

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Abstract

The advent and integration of high-throughput 'omic technologies (e.g., genomics, transcriptomics, proteomics and metabolomics) are becoming instrumental to assist fundamental explorations of the systems biology of organisms. In particular, these technologies now provide unique opportunities for global, molecular investigations of parasites. For example, studies of the transcriptomes (all transcripts in an organism, tissue or cell) of different species and/or developmental stages of parasitic nematodes provide insights into aspects of gene expression, regulation and function, which is a major step to understanding their biology. The purpose of this article was to review salient aspects of the systematics and biology of selected species of parasitic nematodes (particularly key species of the order Strongylida) of socio-economic importance, to describe conventional and advanced sequencing technologies and bioinformatic tools for large-scale investigations of the transcriptomes of these parasites and to highlight the prospects and implications of these explorations for developing novel methods of parasite intervention.

Item ID: 26420
Item Type: Article (Research - C1)
ISSN: 1873-1899
Keywords: transcriptomics; strongylid nematodes; bioinformatics; vaccine targets; drug candidates; ancylostoma-secreted proteins; genomics; next-generation sequencing
Funders: Australian Research Council (ARC), Australian Academy of Science, Australian-American Fullbright Commission, Melbourne Water Corporation, National Health and Medical Research Council (NHMRC), Victorian Life Sciences Computation Initiative, IMB Collaboratory
Date Deposited: 15 Apr 2013 03:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 60%
08 INFORMATION AND COMPUTING SCIENCES > 0803 Computer Software > 080301 Bioinformatics Software @ 10%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 30%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 10%
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