Whole-genome sequence of Schistosoma haematobium

Young, Neil D., Jex, Aaron R., Lo, Bo, Liu, Shiping, Yang, Linfeng, Xiong, Zijun, Li, Yingrui, Cantacessi, Cinzia, Hall, Ross S., Xu, Xun, Chen, Fangyuan, Wu, Xuan, Zerlotini, Adhemar, Oliveira, Guilherme, Hofmann, Andreas, Zhang, Guojie, Fang, Xiaodong, Kang, Yi, Campbell, Bronwyn E., Loukas, Alex, Ranganathan, Shoba, Rollinson, David, Rinaldi, Gabriel, Brindley, Paul J., Yang, Huanming, Wang, Jun, Wang, Jian, and Gasser, Robin B. (2012) Whole-genome sequence of Schistosoma haematobium. Nature Genetics, 44 (2). pp. 221-225.

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Abstract

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide(1). No vaccines are available, and treatment relies on one drug, praziquantel(2). Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer(1,3) and as a predisposing factor for HIV/AIDS(4,5). The parasite is transmitted to humans from freshwater snails'. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease(6) and induce squamous cell carcinoma(7). Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites(8,9). We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

Item ID: 22166
Item Type: Article (Research - C1)
ISSN: 1546-1718
Additional Information:

This paper is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike license, and is freely available to all readers at http://www.nature.com/naturegenetics/.

Funders: Australian Research Council (ARC), National Health and Medical Research Council (NHMRC), Australian Academy of Science, Australian-American Fulbright Commission, Melbourne Water Corporation, Victorian Life Sciences Computation Initiative, IBM Collaboratory
Date Deposited: 28 Jun 2012 16:01
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 60%
08 INFORMATION AND COMPUTING SCIENCES > 0803 Computer Software > 080301 Bioinformatics Software @ 10%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 30%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 10%
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