Publications by:
Andrew K. Sewell
Also publishes as (Andrew k. Sewell, A.K. Sewell)
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Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas R., Dolton, Garry, Miles, John J., Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M., and Sewell, Andrew K. (2016) Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology, 197 (3). pp. 971-982.
Szomolay, Barbara, Liu, Jie, Brown, Paul E., Miles, John J., Clement, Mathew, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J., Sewell, Andrew K., Burrows, Scott R., Roederer, Mario, Price, David A., Wooldridge, Linda, and van den Berg, Hugo A. (2016) Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology, 94 (6). pp. 573-582.
Cole, David K., Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J., and Sewell, Andrew K. (2016) Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 126 (6). pp. 2191-2204.
Theaker, Sarah M., Rius, Cristina, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew, Fuller, Anna, Miles, John J., Cole, David K., Peakman, Mark, Sewell, Andrew K., and Dolton, Garry (2016) T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods, 430. pp. 43-50.
Neller, Michelle A., Ladell, Kristin, McLaren, James E., Matthews, Katherine K., Gostick, Emma, Pentier, Johanne M., Dolton, Garry, Schauenburg, Andrea J.A., Koning, Dan, Fontaine Costa, Ana Isabel C.A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K., van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David A., and Miles, John J. (2015) Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology, 93 (7). pp. 625-633.
Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy E., Schauenburg, Andrea J., Trimby, Andrew, Donia, Marco, Miles, John J., Holland, Christopher J., Cole, David K., Godkin, Andrew J., Peakman, Mark, Straten, Per Thor, Svane, Inge Marie, Sewell, Andrew K., and Dolton, Garry (2015) Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology, 194 (1). pp. 463-474.
Dolton, G., Lissina, A., Skowera, A., Ladell, K., Tungatt, K., Jones, E., Kronenberg-Versteeg, D., Akpovwa, H., Pentier, J.M., Holland, C.J., Godkin, A.J., Cole, D.K., Neller, M.A., Miles, J.J., Price, D.A., Peakman, M., and Sewell, A.K. (2014) Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology, 177 (1). pp. 47-63.
Skowera, Ania, Ladell, Kristin, McLaren, James E., Dolton, Garry, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin M., Miles, John J., Sewell, Andrew K., Price, David A., and Peakman, Mark (2014) β-cell–specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes, 64 (3). pp. 916-925.
Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J.A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., and Cole, David K. (2013) T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry, 288 (26). pp. 18766-18775.
Motozono, Chihiro, Miles, John J., Hasan, Zafrul, Gatanaga, Hiroyuki, Meribe, Stanley C., Price, David A., Oka, Shinichi, Sewell, Andrew K., and Ueno, Takamasa (2013) CD8⁺ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE, 8 (6). e66152. pp. 1-6.
Pentier, Johanne M., Sewell, Andrew K., and Miles, John J. (2013) Advances in T-Cell epitope engineering. Frontiers in Immunology, 4. 133. pp. 1-4.
Ekeruche-Makinde, Julia, Miles, John J., van den Berg, Hugo A., Skowera, Ania, Cole, David K., Dolton, Garry, Schauenburg, Andrea J.A., Tan, Mai Ping, Pentier, Johanne M., Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna M., Clement, Mathew, Williams, Tamsin, Trimby, Andrew, Bailey, Mick, Rizkallah, Pierre, Rossjohn, Jamie, Peakman, Mark, Price, David A., Burrows, Scott R., Sewell, Andrew K., and Wooldridge, Linda (2013) Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood, 121 (7). pp. 1112-1123.
Neller, Michelle A., Sewell, Andrew k., Burrows, Scott R., and Miles, John J. (2012) Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification. British Journal of Haematology, 159 (3). pp. 370-373.
Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S.J., Ladell, Kristin, Miles, John, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda, and Sewell, Andrew K. (2012) T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry, 287 (44). pp. 37269-37281.
Bulek, Anna M., Cole, David K., Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J., Gostick, Emma, Price, David A., Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J., and Sewell, Andrew K. (2012) Structural basis of human β-cell killing by CD8⁺ T cells in Type 1 diabetes. Nature Immunology, 13 (3). pp. 283-289.
Wooldridge, Linda, Ekeruche-Makinde, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John J., Tan, Mai Ping, Dolton, Garry, Clement, Mathew, Llewellyn-Lacey, Sian, Price, David A., Peakman, Mark, and Sewell, Andrew K. (2012) A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry, 287 (2). pp. 1168-1177.
Bridgeman, John S., Sewell, Andrew K., Miles, John J., Price, David A., and Cole, David K. (2012) Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology, 135 (1). pp. 9-18.
Clement, Mathew, Ladell, Kristin, Ekeruche-Makinde, Julia, Miles, John J., Edwards, Emily S.J., Dolton, Garry, Williams, Tamsin, Schauenburg, Andrea J.A., Cole, David K., Lauder, Sarah N., Gallimore, Awen M., Godkin, Andrew J., Burrows, Scott R., Price, David A., Sewell, Andrew K., and Wooldridge, Linda (2011) Anti-CD8 Antibodies Can Trigger CD8⁺ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. Journal of Immunology, 187 (2). pp. 654-663.
Miles, Kim M., Miles, John J., Madura, Florian, Sewell, Andrew K., and Cole, David K. (2011) Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology, 48 (4). pp. 728-732.
Tarbe, Marion, Azcune, Itxaso, Balentová, Eva, Miles, John J., Edwards, Emily E., Miles, Kim M., Do, Priscilla, Baker, Brian M., Sewell, Andrew K., Aizpurua, Jesus M., Douat-Casassus, Céline, and Quideau, Stéphane (2010) Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media. Organic and Biomolecular Chemistry, 8 (23). pp. 5345-5353.
Miles, John J., Bulek, Anna M., Cole, David k., Gostick, Emma, Schauenburg, Andrea J.A., Dolton, Garry, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott, Wooldridge, Linda, Price, David A., Rizkallah, Pierre J., and Sewell, Andrew K. (2010) Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens, 6 (11). e1001198. pp. 1-15.
Cole, David K., Edwards, Emily S.J., Wynn, Katherine K., Clement, Mathew, Miles, John J., Ladell, Kristin, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A., and Sewell, Andrew K. (2010) Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. Journal of Immunology, 185 (4). pp. 2600-2610.
Wooldridge, Linda, Clement, Mathew, Lissina, Anna, Edwards, Emily S.J., Ladell, Kristin, Ekeruche, Julia, Hewitt, Rachel E., Laugel, Bruno, Gostick, Emma, Cole, David K., Debets, Reno, Berrevoets, Cor, Miles, John J., Burrows, Scott R., Price, David A., and Sewell, Andrew K. (2010) MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology, 184 (7). pp. 3357-3366.
Cole, David K., Yuan, Fang, Rizkallah, Pierre J., Miles, John J., Gostick, Emma, Price, David A., Gao, George F., Jakobsen, Bent K., and Sewell, Andrew K. (2009) Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry, 284 (40). pp. 27281-27289.