Miranda-Hernandez, Socorro, Sathkumara Mudiyanselage, Harindra, Zhao, Guangzu, Schofield, Louis, and Kupz, Andreas (2025) Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis. Vaccine, 68. 127912.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution. Download (892kB) | Preview

Abstract

Tuberculosis (TB) remains a major global health challenge claiming over 1 million lives annually. Bacillus Calmette-Gu´erin (BCG), the only licensed vaccine against TB, provides limited efficacy against pulmonary TB in adults and only partial protection against serious disease in children. Hence, the development of safer and more effective new vaccines against TB remains a global health priority. Here we show in a new approach that co- administration of BCG with a novel synthetic glycan conjugate vaccine, corresponding to conserved terminal mannose sequences in Phosphatidyl-myo-inositol-mannosides (PIMs) in the cell envelope of mycobacteria, results in reduced bacterial burden compared to BCG vaccination alone. This first in vivo efficacy study suggests that targeting conserved essential oligosaccharides of mycobacteria is an important factor in improving TB vaccine efficacy.

Item ID:	89726
Item Type:	Article (Research - C1)
ISSN:	1873-2518
Copyright Information:	© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Date Deposited:	26 Nov 2025 23:11
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 50%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100%
	More Statistics