Sharifnia, Amir Masoud, Biros, Erik, and Cleary, Michelle (2025) Understanding Network Meta-Analysis: A Practical Introduction for Nurses. Journal of Advanced Nursing, 81 (8). pp. 5208-5213.

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Abstract

Aims: This paper examines network meta-analysis (NMA) as a methodological advancement in nursing research and discusses considerations for interpreting and applying NMA results in clinical practice. Design and Methods: Methodological discussion. Results: The NMA method simultaneously evaluates multiple interventions by combining direct and indirect evidence. The publication of NMA articles in nursing journals has been increasing. However, interpreting NMA results can be complex and challenging. In this paper, we outline the prerequisites and assumptions of NMA, provide a graphical representation, discuss effect estimation and quality of evidence and give an overview of applying NMA results in clinical practice. Conclusion: NMA is a valuable analytical approach in nursing research that can provide high-level evidence to guide clinical decision-making. Accurate interpretation of NMA findings is necessary to inform clinical practice. This paper serves as an introduction to NMA for nurses unfamiliar with the approach. Implications for the Profession: NMA is a powerful statistical technique for assessing the relative effectiveness of different nursing interventions and informing evidence-based nursing guidelines. When interpreting the results, nurses should consider the certainty of evidence and the practical value of the results and be cautious of misleading conclusions. Impact: NMA is a recent analytical method in nursing research. This practical introduction seeks to enhance comprehension of NMA and the interpretation and application of NMA findings in clinical practice. NMA is a robust statistical technique to assess the relative effectiveness of various nursing interventions. Reporting Method: In the methodological discussion guide, no new data was generated. A hypothetical dataset was used. Patient or Public Contribution: This methodological paper contributes to understanding NMA and interpreting its results, integrating it into clinical practice, and improving patient outcomes.

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