Bose, B., Shenoy, S., Reza, M.M., McFarlane, C.D., Sharma, M., and Kambadur, R. (2014) Plasticity of muscle derived stem cells to undergo pluripotent conversion without pluripotency factors or small molecules. Cytotherapy, 16 (4). 246. S71.

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Abstract

Induction of pluripotency in somatic cells from multiple origins have been, in vogue since almost a decade using pluripotency factors/genes, Oct3/4, Sox2, Klf4, c-Myc, Lin28 and small molecules like inhibitors of BMP2, MAP kinase and GSK3β. Here, we show the induced pluripotency of otherwise, multipotent, muscle derived stem cells (MDSC) obtained from hind limb muscles of myostatin null (Mstn-/-) mouse.Induction of pluripotency in somatic cells from multiple origins have been, in vogue since almost a decade using pluripotency factors/genes, Oct3/4, Sox2, Klf4, c-Myc, Lin28 and small molecules like inhibitors of BMP2, MAP kinase and GSK3β. Here, we show the induced pluripotency of otherwise, multipotent, muscle derived stem cells (MDSC) obtained from hind limb muscles of myostatin null (Mstn-/-) mouse.

Item ID:	87618
Item Type:	Article (Abstract)
ISSN:	14653249
Keywords:	MyoD, Muscle, stem cells
Copyright Information:	Copyright © 2014 Published by Elsevier Inc.
Additional Information:	Presented at the 20th Anniversary Meeting of the International Society for Cell Therapy (ISCT), Paris, France, April 23-26, 2014.
Date Deposited:	02 Sep 2025 01:43
FoR Codes:	31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310102 Cell development, proliferation and death @ 100%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
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