Kalo, Eric, Read, Scott, and Ahlenstiel, Golo (2022) Reprogramming-Evolving Path to Functional Surrogate β-Cells. Cells, 11. 2813.

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Abstract

Numerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages into insulin-secreting β-cells. In this review, we explore emerging reprograming pathways that aim to generate bone fide insulin producing cells. We focus on small molecules and key transcriptional regulators that orchestrate phenotypic conversion and maintenance of engineered cells.

Item ID:	86137
Item Type:	Article (Research - C1)
ISSN:	2073-4409
Keywords:	β-cell; diabetes mellitus; cell sources; reprogramming; insulin
Related URLs:	https://www.mdpi.com/2073-4409/11/18/281...
Copyright Information:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Date Deposited:	16 Jul 2025 23:46
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320606 Regenerative medicine (incl. stem cells) @ 70% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320208 Endocrinology @ 20% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310102 Cell development, proliferation and death @ 10%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50%
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