Carrai, Maura, Steinke, Verena, Vodicka, Pavel, Pardini, Barbara, Rahner, Nils, Holinski-Feder, Elke, Morak, Monika, Schackert, Hans K.S., Gorgens, Heike, Stemmler, Susanne, Betz, Beate, Kloor, Matthias, Engel, Christoph, Buttner, Reinhard, Naccarati, Alessio, Vodickova, Ludmila, Novotny, Jan, Stein, Angelika, Hemminki, Kari, Propping, Peter, Forsti, Asta, Canzian, Federico, Barale, Roberto, and Campa, Daniele (2011) Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin. PLoS ONE, 6 (6). e20464.

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Abstract

Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99–1.67; Pvalue = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06– 1.75; Pvalue = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12–1.61; Pvalue = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.

Item ID:	84452
Item Type:	Article (Research - C1)
ISSN:	1932-6203
Copyright Information:	© 2011 Carrai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Date Deposited:	20 Jan 2025 22:35
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321103 Cancer genetics @ 50% 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310501 Anthropological genetics @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50%
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