Sex, Endothelial Cell Functions, and Peripheral Artery Disease
Cartland, Sian P., Stanley, Christopher P., Bursill, Christina, Passam, Freda, Figtree, Gemma A., Patel, Sanjay, Loa, Jacky, Golledge, Jonathan, Robinson, David A., Aitken, Sarah J., and Kavurma, Mary M. (2023) Sex, Endothelial Cell Functions, and Peripheral Artery Disease. International Journal of Molecular Sciences, 24 (24). 17439.
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Abstract
Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention. In addition to a potential unconscious bias faced by women with PAD in the health system, with underdiagnosis, and lower rates of guideline-based therapy, fundamental biological differences between men and women may be important. In this review, we highlight sexual dimorphisms in endothelial cell functions and how they may impact PAD pathophysiology in women. Understanding sex-specific mechanisms in PAD is essential for the development of new therapies and personalized care for patients with PAD.
Item ID: | 81561 |
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Item Type: | Article (Research - C1) |
ISSN: | 1422-0067 |
Keywords: | endothelial cell dysfunction, peripheral artery disease, sex differences |
Copyright Information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Date Deposited: | 07 Feb 2024 01:59 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100% |
SEO Codes: | 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100% |
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