Mood Disorders: The Gut Bacteriome and Beyond
McGuinness, Amelia J., Loughman, Amy, Foster, Jane A., and Jacka, Felice (2024) Mood Disorders: The Gut Bacteriome and Beyond. Biological Psychiatry, 95 (4). pp. 319-328.
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Abstract
Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, while substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology. Beyond the gut bacteriome, research into lesser explored components of the gut microbiome, including the gut virome, mycobiome, archaeome, and parasitome, is increasingly suggesting relevance in psychiatry. The contribution of microbiomes beyond the gut, including the oral, lung, and small intestinal microbiomes, to human health and pathology should not be overlooked. Increasing both our awareness and understanding of these less traversed fields of research are critical to improving the therapeutic benefits of treatments targeting the gut microbiome, including fecal microbiome transplantation, postbiotics and biogenics, and dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required to fully elucidate how these different microbial components and distinct microbial niches interact with each other and their human hosts. Excitingly, we may be at the start of the next microbiome revolution and thus one step closer to informing the field of precision psychiatry to improve outcomes for those living with mental illness.
Item ID: | 81465 |
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Item Type: | Article (Research - C1) |
ISSN: | 1873-2402 |
Keywords: | Bipolar disorder, Depression, Major depressive disorder, Microbiome, Mood disorders |
Copyright Information: | © 2023 Society of Biological Psychiatry. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Funders: | National Health and Medical Research Council of Australia (NHMRC) |
Date Deposited: | 07 Mar 2024 01:41 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321002 Food properties (incl. characteristics and health benefits) @ 50% |
SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280112 Expanding knowledge in the health sciences @ 50% |
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