Q fever - immune responses and novel vaccine strategies
Redden, Patricia, Parker, Kaitland, Henderson, Sinead, Fourie, Phillip, Agnew, Linda, Stenos, John, Graves, Stephen, Govan, Brenda, Norton, Robert, and Ketheesan, Natkunam (2023) Q fever - immune responses and novel vaccine strategies. Future Microbiology, 18 (16). pp. 1185-1196.
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Abstract
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. It is an occupational risk for employees of animal industries and is associated with contact with wildlife and domestic animals. Although Q fever infection may be asymptomatic, chronic sequelae such as endocarditis occur in 5% of symptomatic individuals. Disease outcomes may be predicted through measurement of immune correlates. Vaccination is the most efficient method to prevent Q fever. Currently, Q-VAX is the only licenced human vaccine. Q-VAX is highly effective; however, individuals previously exposed to C. burnetii are at risk of adverse reactions. This review examines the immunological responses of acute and chronic Q fever and the efforts to provide a safer and cost-effective Q fever vaccine.
| Item ID: | 81430 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1746-0921 |
| Keywords: | Coxiella burnetii, immune responses, immunisation, Q fever, Q-VAX, vaccination |
| Copyright Information: | This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Date Deposited: | 02 Apr 2024 03:03 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 50% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100% |
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