Effects of ketogenic diets and ketone supplementation on the nervous system during development: Applications to autism spectrum disorders and schizophrenia

Longhitano, Calogero, Kraeuter, Ann-Katrin, Gordon, Shaileigh, and Sarnyai, Zoltan (2023) Effects of ketogenic diets and ketone supplementation on the nervous system during development: Applications to autism spectrum disorders and schizophrenia. In: Martin, Colin R., Patel, Vinood B., and Preedy, Victor R., (eds.) Diet and Nutrition in Neurological Disorders. Academic Press, London, United Kingdom, pp. 869-889.

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Abstract

Schizophrenia and autism spectrum disorders (ASD) are among the neurodevelopmental disorders that have recently been conceptualized as disorders of brain energy metabolism. A variety of pathophysiological mechanisms might concur to the development of the disorders, to include altered brain glucose metabolism resulting in inefficient processing of glucose as the primary source of metabolic energy (ATP) via glycolysis as well as the abnormal functioning of the mitochondria. The ketogenic diet is a very low-carbohydrate, high-protein, and high-fat diet that induces a physiological state of ketosis in humans and other mammals. In the absence of glycolysis, ketone bodies enter the neural cell metabolism to produce ATP via the TCA cycle and might thus act as an alternative energy substrate. Preliminary data from preclinical and human studies confirm a measurable effect of dietary interventions to re-establish efficient brain energy metabolism.

Item ID: 80399
Item Type: Book Chapter (Research - B1)
ISBN: 9780323898348
Keywords: Autism spectrum disorder, Cell energy metabolism, Ketogenic diet, Ketosis, Nutritional interventions, Schizophrenia
Copyright Information: Copyright © 2023 Elsevier Inc. All rights reserved.
Date Deposited: 04 Mar 2024 03:23
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321001 Clinical nutrition @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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