Antimicrobial graphene-based coatings for biomedical implant applications
Romo-Rico, Jesus, Bright, Richard, Krishna, Smriti Murali, Vasilev, Krasimir, Golledge, Jonathan, and Jacob, Mohan V. (2023) Antimicrobial graphene-based coatings for biomedical implant applications. Carbon Trends, 12. 100282.
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Abstract
Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.
| Item ID: | 80321 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2667-0569 |
| Keywords: | Antimicrobial, Biocompatible, Coatings, Graphene, Implant |
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| Copyright Information: | © 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Funders: | National Health and Medical Research Council (NHMRC), Australian Research Council (ARC) |
| Projects and Grants: | NHMRC GNT1194466, ARC DP180101254 |
| Date Deposited: | 18 Jan 2024 00:17 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320699 Medical biotechnology not elsewhere classified @ 50% 40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials @ 50% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100% |
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