MHC-dependent survival in a wild population: evidence for hidden genetic benefits gained through extra-pair fertilizations

Brouwer, Lyanne, Barr, Iain, van de Pol, Martijn, Burke, Terry, Komdeur, Jan, and Richardson, David S. (2010) MHC-dependent survival in a wild population: evidence for hidden genetic benefits gained through extra-pair fertilizations. Molecular Ecology, 19 (16). pp. 3444-3455.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only


Females should prefer to be fertilized by males that increase the genetic quality of their offspring. In vertebrates, genes of the major histocompatibility complex (MHC) play a key role in the acquired immune response and have been shown to affect mating preferences. They are therefore important candidates for the link between mate choice and indirect genetic benefits. Higher MHC diversity may be advantageous because this allows a wider range of pathogens to be detected and combated. Furthermore, individuals harbouring rare MHC alleles might better resist pathogen variants that have evolved to evade common MHC alleles. In the Seychelles warbler, females paired with low MHC-diversity males elevate the MHC diversity of their offspring to levels comparable to the population mean by gaining extra-pair fertilizations. Here, we investigate whether increased MHC diversity results in higher life expectancy and whether there are any additional benefits of extra-pair fertilizations. Our 10-year study found a positive association between MHC diversity and juvenile survival, but no additional survival advantage of extra-pair fertilizations. In addition, offspring with a specific allele (Ase-ua4) had a fivefold longer life expectancy than offspring without this allele. Consequently, the interacting effects of sexual selection and pathogen-mediated viability selection appear to be important for maintaining MHC variation in the Seychelles warbler. Our study supports the prediction that MHC-dependent extra-pair fertilizations result in genetic benefits for offspring in natural populations. However, such genetic benefits might be hidden and not necessarily apparent in the widely used fitness comparison of extra- and within-pair offspring.

Item ID: 80095
Item Type: Article (Research - C1)
ISSN: 1365-294X
Keywords: mark-recapture survival analysis, mate choice, MHC class I, pathogens, Seychelleswarbler, viability selection
Copyright Information: © 2010 Blackwell Publishing Ltd.
Date Deposited: 01 Sep 2023 05:18
FoR Codes: 31 BIOLOGICAL SCIENCES > 3103 Ecology > 310301 Behavioural ecology @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page