Evaluation of fertility disrupting potentials of Abrus precatorius seed extracts in male rats for arresting spermatogenesis and suppressed fertility in vivo
Talukder, Saranika, Sarker, Subir, Hossain, Md Afzal, Khan, Md Abu Hadi, Hannan, Md Abdul, and Islam, M. Tofazzal (2014) Evaluation of fertility disrupting potentials of Abrus precatorius seed extracts in male rats for arresting spermatogenesis and suppressed fertility in vivo. Pakistan Veterinary Journal, 34 (1). pp. 18-23.
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Abstract
This study was aimed to evaluate the contraceptive potentials of different chemical extracts of Abrus precatorius seeds in male albino rats. The active ingredients of crushed seeds were extracted with 60% aqueous acetone and then partitioned consecutively with n-hexane, ethyl acetate, methanol and water. Water suspended chemical fractions at different doses were administered orally to the male rats for 40 days. Effects of different treatments on various male reproductive endpoints and contraceptive efficacy were evaluated. Oral administration of both organic (methanol soluble at 50 and 75 mg/kg BW) and aqueous soluble A. precatorius seed extracts caused infertility in studied subjects at varying degrees. At necropsy, average weights of testes, epididymis, ventral prostate gland and seminal vesicles were decreased significantly. Histology of testes revealed marked atrophy of the seminiferous tubules characterized by disruption of the germinal epithelium and atrophy of the Leydig cells. Epididymis also showed histological alterations. Hormonal assay revealed a significant decrease in serum levels of testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) that possibly resulted in suppressed spermatogenesis of male rats. These effects lead to the reduction of pregnancy rate of untreated fertile female rats while mated with the methanol extract (50 and 75 mg/kg BW) and aqueous extract-treated male rats. The results show that A. precatorius seed extract causes suppression of spermatogenesis and fertility, thereby suggesting the potential of this plant in the regulation of male fertility. © 2013 PVJ. All rights reserved.
Item ID: | 79874 |
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Item Type: | Article (Research - C1) |
ISSN: | 0253-8318 |
Keywords: | Abrus precatorius seed, Antifertility, Male rats, Spermatogenesis |
Copyright Information: | ©2013 PVJ. All rights reserved. The management of the Pakistan Veterinary Journal ensures that the manuscripts published in it are freely accessible online/ via internet immediately upon publication, without any cost/barrier of subscription/registration to the readers universally. |
Date Deposited: | 03 Jan 2024 07:03 |
FoR Codes: | 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300911 Veterinary pharmacology @ 100% |
SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280101 Expanding knowledge in the agricultural, food and veterinary sciences @ 100% |
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