Characterization of peptides derived from marine organisms
Schmidt, Casey Ann (2022) Characterization of peptides derived from marine organisms. PhD thesis, James Cook University.
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Abstract
Casey Schmidt studied peptides from marine organisms in a range of different aspects focusing on their potential use as drug leads. She investigated a previously described peptide from the venom of a cone snail and the relationship between its three-dimensional structure and its function. She also discovered and characterized five new peptides from the stony coral Heliofungia actiniformis.
| Item ID: | 79785 |
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| Item Type: | Thesis (PhD) |
| Keywords: | coral, sea anemone, toxin, nematocyst, venom, peptides |
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| Copyright Information: | Copyright © 2022 Casey Ann Schmidt. |
| Additional Information: | Four publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: [Chapter 2] Schmidt, Casey A., Daly, Norelle L., and Wilson, David T. (2019) Coral venom toxins. Frontiers in Ecology and Evolution, 7. 320. [Chapter 3] Giribaldi, Julien, Haufe, Yves, Evans, Evans R.J., Amar, Muriel, Durner, Anna, Schmidt, Casey, Faucherre, Adèle, Moha Ou Maati, Hamid, Enjalbal, Christine, Molgó, Jordi, Servent, Denis, Wilson, David T., Daly, Norelle L., and Nicke, Annette (2020) Backbone cyclization turns a venom peptide into a stable and equipotent ligand at both muscle and neuronal nicotinic receptors. Journal of Medicinal Chemistry, 63 (21). pp. 12682-12692. [Chapter 4] Schmidt, Casey A., Wilson, David T., Cooke, Ira, Potriquet, Jeremy, Tungatt, Katie, Muruganandah, Visai, Boote, Chloe, Kuek, Felicity, Miles, John J., Kupz, Andreas, Ryan, Stephanie, Loukas, Alex, Bansal, Paramjit S., Takjoo, Rozita, Miller, David J., Peigneur, Steve, Tytgat, Jan, and Daly, Norelle (2020) Identification and characterization of a peptide from the stony coral Heliofungia actiniformis. Journal of Natural Products, 83 (11). pp. 3454-3463. [Chapter 5] Schmidt, Casey A., Cooke, Ira, Wilson, David T., Miller, David J., Peigneur, Steve, Tytgat, Jan, Field, Matthew, Takjoo, Rozita, Smout, Michael J., Loukas, Alex, and Daly, Norelle L. (2022) Newly Discovered Peptides from the Coral Heliofungia actiniformis Show Structural and Functional Diversity. Journal of Natural Products, 85 (7). pp. 1789-1798. |
| Date Deposited: | 14 Aug 2023 04:16 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 35% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310101 Analytical biochemistry @ 35% 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 30% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 50% 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50% |
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