Cross-reactive epitopes and their role in food allergy
Kamath, Sandip D., Bublin, Merima, Kitamura, Katsumasa, Matsui, Teruaki, Ito, Komei, and Lopata, Andreas L. (2023) Cross-reactive epitopes and their role in food allergy. Journal of Allergy and Clinical Immunology, 151 (5). pp. 1178-1190.
|
PDF (Published Version)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Allergenic cross-reactivity among food allergens complicates the diagnosis and management of food allergy. This can result in many patients being sensitized (having allergen-specific IgE) to foods without exhibiting clinical reactivity. Some food groups such as shellfish, fish, tree nuts, and peanuts have very high rates of cross-reactivity. In contrast, relatively low rates are noted for grains and milk, whereas many other food families have variable rates of cross-reactivity or are not well studied. Although classical cross-reactive carbohydrate determinants are clinically not relevant, α-Gal in red meat through tick bites can lead to severe reactions. Multiple sensitizations to tree nuts complicate the diagnosis and management of patients allergic to peanut and tree nut. This review discusses cross-reactive allergens and cross-reactive carbohydrate determinants in the major food groups, and where available, describes their B-cell and T-cell epitopes. The clinical relevance of these cross-reactive B-cell and T-cell epitopes is highlighted and their possible impact on allergen-specific immunotherapy for food allergy is discussed.
Item ID: | 78508 |
---|---|
Item Type: | Article (Research - C1) |
ISSN: | 1097-6825 |
Keywords: | allergenic cross-reactivity, Allergens, B-cell, clinical cross-reactivity, cross-reactive epitope, cross-reactive IgE, food allergy, IgE antibody, T-cell, tropomyosin |
Copyright Information: | © 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Date Deposited: | 24 Oct 2023 00:30 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 100% |
SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100% |
Downloads: |
Total: 224 Last 12 Months: 26 |
More Statistics |