Thoracic Surgery and the Elderly; Is Lobectomy Safe in Octogenarians?
Kirk, Frazer, Chang, Shantel, Yong, Matthew S., He, Cheng, Hughes, Ian, Yadav, Sumit, Lo, Wing, Cole, Christopher, Windsor, Morgan, Naidoo, Rishendran, and Stroebel, Andrie (2023) Thoracic Surgery and the Elderly; Is Lobectomy Safe in Octogenarians? Heart, Lung and Circulation, 32 (6). pp. 755-762.
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Abstract
Purpose: Non-small cell lung cancer is the most common malignancy of the elderly, with 5-year survival estimates of 16.8%. The prognostic benefit of surgical resection for early lung cancer is irrefutable and maintained irrespective of age, even in patients over 75 years. Concerningly, despite the prognostic benefit of surgery there are deviations from standard treatment protocols with increasing age due to concerns of increased morbidity and mortality with surgery, without evidence to support this.
Method: A state-wide retrospective registry study of Queensland's Cardiac Outcomes Registry's (QCOR) Thoracic Database examining the influence of age on the safety of Lung Resection (1 January 2016–20 April 2022).
Results: This included 1,232 patients, mean age at surgery was 66 years (range 14–91 years), with 918 thoracotomies performed. Three deaths occurred within 30-days (0.24%). Octogenarians (n=60) had lower rates of smoking (26% vs 6%), respiratory, cardiovascular, and cerebrovascular disease suggesting this subset of patients is carefully selected. Octogenarian status was not associated with an increased all-cause morbidity (p=0.09) or 30-day mortality (p=0.06). Further to this it was not associated with re-operation (4.4% vs 8.3%, p=0.1), increased postoperative stay (6.66 vs 6.65 days, p=0.99) or myocardial infarction. An independent predictor of morbidity was male sex (OR 1.58, CI 1.2–2.1 p=0.001).
Conclusion: Age ≥80 years did not increase surgical morbidity or mortality in the appropriately selected patient and should not be a barrier to referral for consideration of surgical resection.
| Item ID: | 78480 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1444-2892 |
| Keywords: | Elderly, Frailty, Lung cancer, Morbidity, Mortality, Octogenarian, Thoracic surgery |
| Copyright Information: | © 2023 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Date Deposited: | 24 Oct 2023 01:03 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320226 Surgery @ 100% |
| SEO Codes: | 20 HEALTH > 2005 Specific population health (excl. Indigenous health) > 200502 Health related to ageing @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50% |
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