Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds

Koushik, Tejas M., Miller, Catherine M., and Antunes, Elsa (2023) Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds. Advanced Healthcare Materials, 12 (9). 2202766.

PDF (Published Version) - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (11MB) | Preview
View at Publisher Website:


Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, and the understanding of bone healing pathways have opened new avenues of research. The dual responsibility of BTE scaffolds in providing load-bearing capability and interaction with the local extracellular matrix to promote bone healing is a challenge in synthetic scaffolds. This article describes the usage and processing of multi-materials and hierarchical structures to mimic the structure of natural bone tissues to function as bioactive and load-bearing synthetic scaffolds. The first part of this literature review describes the physiology of bone healing responses and the interactions at different stages of bone repair. The following section reviews the available literature on biomaterials used for BTE scaffolds followed by some multi-material approaches. The next section discusses the impact of the scaffold's structural features on bone healing and the necessity of a hierarchical distribution in the scaffold structure. Finally, the last section of this review highlights the emerging trends in BTE scaffold developments that can inspire new tissue engineering strategies and truly develop the next generation of synthetic scaffolds.

Item ID: 78327
Item Type: Article (Research - C1)
ISSN: 2192-2659
Keywords: biomaterials, bone tissue engineering, hierarchical structures
Copyright Information: © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Date Deposited: 25 May 2023 03:48
FoR Codes: 40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering @ 30%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320699 Medical biotechnology not elsewhere classified @ 70%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 30%
28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280110 Expanding knowledge in engineering @ 70%
Downloads: Total: 394
Last 12 Months: 23
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page