Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection

Nisa, Annuurun, Kipper, Franciele C., Panigrahy, Dipak, Tiwari, Sangeeta, Kupz, Andreas, and Subbian, Selvakumar (2022) Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection. American Journal of Physiology: cell physiology, 323 (5). C1444-C1474.

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Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading infectious disease of humans worldwide. One of the main histopathological hallmarks of TB is the formation of granulomas comprised of elaborately organized aggregates of immune cells containing the pathogen. Dissemination of Mtb from infected cells in the granulomas due to host and mycobacterial factors induces multiple cell death modalities in infected cells. Based on molecular mechanism, morphological characteristics, and signal dependency, there are two main categories of cell death: programmed and nonprogrammed. Programmed cell death (PCD), such as apoptosis and autophagy, is associated with a protective response to Mtb by keeping the bacteria encased within dead macrophages that can be readily phagocytosed by arriving in uninfected or neighboring cells. In contrast, non-PCD necrotic cell death favors the pathogen, resulting in bacterial release into the extracellular environment. Multiple types of cell death in the PCD category, including pyroptosis, necroptosis, ferroptosis, ETosis, parthanatos, and PANoptosis, may be involved in Mtb infection. Since PCD pathways are essential for host immunity to Mtb, therapeutic compounds targeting cell death signaling pathways have been experimentally tested for TB treatment. This review summarizes different modalities of Mtb-mediated host cell deaths, the molecular mechanisms underpinning host cell death during Mtb infection, and its potential implications for host immunity. In addition, targeting host cell death pathways as potential therapeutic and preventive approaches against Mtb infection is also discussed.

Item ID: 77159
Item Type: Article (Research - C1)
ISSN: 1522-1563
Keywords: cell death signaling, granuloma, host-directed therapy, immune cells, inflammation
Copyright Information: Copyright © 2022 the American Physiological Society.
Date Deposited: 04 Jan 2023 07:46
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310701 Bacteriology @ 20%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 40%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50%
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