Surfaces Containing Sharp Nanostructures Enhance Antibiotic Efficacy

Bright, Richard, Hayles, Andrew, Wood, Jonathan, Palms, Dennis, Brown, Toby, Barker, Dan, and Vasilev, Krasimir (2022) Surfaces Containing Sharp Nanostructures Enhance Antibiotic Efficacy. Nano Letters, 22 (16). pp. 6724-6731.

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The ever-increasing rate of medical device implantations is met by a proportionately high burden of implant-associated infections. To mitigate this threat, much research has been directed toward the development of antibacterial surface modifications by various means. One recent approach involves surfaces containing sharp nanostructures capable of killing bacteria upon contact. Herein, we report that the mechanical interaction between Staphylococcus aureus and such surface nanostructures leads to a sensitization of the pathogen to the glycopeptide antibiotic vancomycin. We demonstrate that this is due to cell wall damage and impeded bacterial defenses against reactive oxygen species. The results of this study promise to be impactful in the clinic, as a combination of nanostructured antibacterial surfaces and antibiotics commonly used in hospitals may improve antimicrobial therapy strategies, helping clinicians to prevent and treat implant-associated infections using reduced antibiotic concentrations instead of relying on invasive revision surgeries with often poor outcomes.

Item ID: 77001
Item Type: Article (Research - C1)
ISSN: 1530-6992
Keywords: antibacterial, antibiotics, biomimetics, hydrothermal etching, implant-associated infections, nanostructure, nanostructures
Funders: National Health and Medical Research Council (NHMRC), Australian Research Council (ARC)
Projects and Grants: NHMRC GNT1194466, ARC DP180101254
Date Deposited: 23 Mar 2023 04:33
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320699 Medical biotechnology not elsewhere classified @ 50%
40 ENGINEERING > 4018 Nanotechnology > 401807 Nanomaterials @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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