Chronology of natural selection in Oceanian genomes
Brucato, Nicolas, André, Mathilde, Hudjashov, Georgi, Mondal, Mayukh, Cox, Murray P., Leavesley, Matthew, and Ricaut, François Xavier (2022) Chronology of natural selection in Oceanian genomes. iScience, 25 (7). 104583.
|
PDF (Published Version)
- Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
Abstract
As human populations left Asia to first settle in Oceania around 50,000 years ago, they entered a territory ecologically separated from the Old World for millions of years. We analyzed genomic data of 239 modern Oceanian individuals to detect and date signals of selection specific to this region. Combining both relative and absolute dating approaches, we identified a strong selection pattern between 52,000 and 54,000 years ago in the genomes of descendants of the first settlers of Sahul. This strikingly corresponds to the dates of initial settlement as inferred from archaeological evidence. Loci under selection during this period, some showing enrichment in Denisovan ancestry, overlap genes involved in the immune response and diet, especially based on plants. Pathogens and natural resources, especially from endemic plants, therefore appear to have acted as strong selective pressures on the genomes of the first settlers of Sahul.
| Item ID: | 76471 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2589-0042 |
| Keywords: | Biological sciences, Evolutionary biology, Genetics, Genomics |
| Copyright Information: | © 2022 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Date Deposited: | 23 Mar 2023 05:56 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3104 Evolutionary biology > 310410 Phylogeny and comparative analysis @ 70% 43 HISTORY, HERITAGE AND ARCHAEOLOGY > 4399 Other history, heritage and archaeology > 439999 Other history, heritage and archaeology not elsewhere classified @ 30% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280113 Expanding knowledge in history, heritage and archaeology @ 50% |
| Downloads: |
Total: 478 Last 12 Months: 8 |
| More Statistics |
Actions (Repository Staff Only)
 |
Item Control Page |