Rational vaccine development for malaria from genomic sequence information

Seid, Mengistu Endris (2020) Rational vaccine development for malaria from genomic sequence information. PhD thesis, James Cook University.

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View at Publisher Website: https://doi.org/10.25903/gfn2-tc45


Malaria remains a global public health problem. Traditional vaccine development efforts spanning many decades have not been successful. Working towards a rationally designed genome-based vaccine, Mengistu Seid has characterized 14 novel P. falciparum antigens identified by proteome-wide T cell screening. Almost all antigens were immunogenic and protective against cross-species parasite challenge.

Item ID: 75448
Item Type: Thesis (PhD)
Keywords: Plasmodium falciparum, malaria, vaccine development, genomics, T cells, parasites
Copyright Information: Copyright © 2020 Mengistu Endris Seid.
Date Deposited: 11 Jul 2022 05:11
FoR Codes: 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310509 Genomics @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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