Resident memory t cells and their role within the liver
Ghilas, Sonia, Valencia-Hernandez, Ana Maria, Enders, Matthias H., Heath, William R., and Fernandez-Ruiz, Daniel (2020) Resident memory t cells and their role within the liver. International Journal of Molecular Sciences, 21 (22). 8565.
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Abstract
Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses—the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM ) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.
| Item ID: | 75231 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1422-0067 |
| Keywords: | Liver, Memory CD8, T cells +, Resident memory T cells |
| Copyright Information: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Funders: | Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC) |
| Projects and Grants: | ARC CE140100011, NHMRC 113293, NHMRC 1105817, NHMRC 154457 |
| Date Deposited: | 16 Aug 2022 01:34 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 100% |
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