Genetic approaches for increasing fitness in endangered species

Kosch, Tiffany A., Waddle, Anthony W., Cooper, Caitlin A., Zenger, Kyall R., Garrick, Dorian J., Berger, Lee, and Skerratt, Lee F. (2022) Genetic approaches for increasing fitness in endangered species. Trends in Ecology & Evolution, 37 (4). pp. 332-345.

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The global rate of wildlife extinctions is accelerating, and the persistence of many species requires conservation breeding programs. A central paradigm of these programs is to preserve the genetic diversity of the founder populations. However, this may preserve original characteristics that make them vulnerable to extinction. We introduce targeted genetic intervention (TGI) as an alternative approach that promotes traits that enable species to persist in the face of threats by changing the incidence of alleles that impact on fitness. The TGI toolkit includes methods with established efficacy in model organisms and agriculture but are largely untried for conservation, such as synthetic biology and artificial selection. We explore TGI approaches as a species-restoration tool for intractable threats including infectious disease and climate change.

Item ID: 73281
Item Type: Article (Research - C1)
ISSN: 1872-8383
Keywords: genomic selection, conservation breeding, eQTL, GWAS, synthetic biology, assisted evolution
Copyright Information: © 2021 Elsevier Ltd. All rights reserved.
Funders: Australian Research Council (ARC)
Projects and Grants: ARC FT190100462, ARC LP200301370
Date Deposited: 30 Mar 2022 07:49
FoR Codes: 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310509 Genomics @ 50%
31 BIOLOGICAL SCIENCES > 3104 Evolutionary biology > 310405 Evolutionary ecology @ 50%
SEO Codes: 18 ENVIRONMENTAL MANAGEMENT > 1899 Other environmental management > 189999 Other environmental management not elsewhere classified @ 100%
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