Association of Allergic Symptoms in the First 2 Years of Life With Sleep Outcomes Among Chinese Toddlers

Chen, Yujing, Lin, Lizi, Hong, Bin, Karatela, Shamshad, Pan, Wenting, Wu, Shengchi, Tang, Nu, Wang, Yuxuan, Jing, Jin, and Cai, Li (2022) Association of Allergic Symptoms in the First 2 Years of Life With Sleep Outcomes Among Chinese Toddlers. Frontiers in Pediatrics, 9. 791369.

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Background: Previous studies have linked allergic symptoms to sleep in children, but the associations might be different when considering different types of allergic symptoms or sleep outcomes. Moreover, the combined effects of multiple allergic symptoms remain unclear in early life. This study aimed to investigate the associations between multiple allergic symptoms and sleep outcomes in early life.

Methods: We included 673 toddlers aged 2 years from a birth cohort in Guangzhou, China. We identified allergic symptoms (skin, eyes and nose, gastrointestinal tract, mouth and lips, and wheeze) within 2 years via standard questionnaires. Sleep outcomes including sleep duration and quality over the past month were assessed based on the Chinese version of the Brief Infant Sleep Questionnaire. Associations between allergic symptoms and sleep outcomes were examined using multivariable linear regression and logistic regression.

Results: Compared to children without allergic symptoms, children with allergic nasal and ocular symptoms had higher odds of frequent nighttime awakenings (OR = 1.41; 95% CI: 1.03, 1.93) and irregular sleep (OR = 1.45, 95% CI: 1.05, 2.00); children with allergic gastrointestinal symptoms slept 0.28 h less during nighttime (95% CI: -0.48, -0.07) and 0.25 h less per day (95% CI: -0.43, -0.08), and had 59% higher odds of irregular sleep (95% CI: 1.24, 2.04). We also found significant association of multiple allergic symptoms with shortened nighttime sleep duration and increased irregular sleep. Whereas, allergic skin, mouth and lips, and wheeze symptoms were not significantly associated with sleep outcomes.

Conclusion: Allergic symptoms within 2 years of age were adversely associated with sleep outcomes, which highlight the importance of early screening of allergic symptoms in toddlers in order to improve their sleep outcomes.

Item ID: 72352
Item Type: Article (Research - C1)
ISSN: 2296-2360
Keywords: allergic symptoms,allergic disease,sleep disturbance,sleep duration,toddler
Copyright Information: © 2022 Chen, Lin, Hong, Karatela, Pan, Wu, Tang, Wang, Jing and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Date Deposited: 09 Feb 2022 14:04
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3006 Food sciences > 300603 Food nutritional balance @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321005 Public health nutrition @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321302 Infant and child health @ 20%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200410 Nutrition @ 100%
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