Massively parallel sequencing in hereditary prostate cancer families reveals a rare risk variant in the DNA repair gene, RAD51C
Marthick, James R., Raspin, Kelsie, Foley, Georgea R., Blackburn, Nicholas B., Banks, Annette, Donovan, Shaun, Malley, Roslyn C., Field, Matthew A., Stanford, Janet L., Ostrander, Elaine A., FitzGerald, Liesel M., and Dickinson, Joanne L. (2021) Massively parallel sequencing in hereditary prostate cancer families reveals a rare risk variant in the DNA repair gene, RAD51C. European Journal of Cancer, 159. pp. 52-55.
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Abstract
[Extract] Dear Editor, Global statistics show that prostate cancer (PrCa) is the second most common non-cutaneous cancer diagnosed in men, and currently, it is the most commonly diagnosed cancer in Australian men [1]. While PrCa is a clinically complex, heterogeneous disease, it is one of the most heritable common cancers, with family history a strong predictor of susceptibility [2]. However, the identification of rare, high-risk germline variants for PrCa has lagged significantly behind other heritable cancers [3].
| Item ID: | 72279 |
|---|---|
| Item Type: | Article (Commentary) |
| ISSN: | 1879-0852 |
| Copyright Information: | © 2021 Elsevier Ltd. All rights reserved. |
| Funders: | National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | NHMRC APP5121190 |
| Date Deposited: | 09 Feb 2022 12:47 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310204 Genomics and transcriptomics @ 50% 31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310208 Translational and applied bioinformatics @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100% |
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