Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus

Du, Qingdan, Huang, Yen-hua, Bajpai, Abhishek, Frosig- Jorgensen, Majbrit, Zhao, Guangzu, and Craik, David J. (2020) Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus. Journal of Natural Products, 83 (12). pp. 3736-3743.

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Hybanthus enneaspermus is an Indian folk medicinal herb that has been widely used as a libido enhancer. This plant belongs to the Violaceae plant family, which ubiquitously contains disulfide-rich cyclic peptides named cyclotides. Cyclotides are an expanding plant-derived peptide family with numerous interesting bioactivities, and their unusual stability against proteolysis has attracted much attention in drug design applications. Recently, H. enneaspermus has been reported to be a rich source of cyclotides, and hence, it was of interest to investigate whether cyclotides contribute to its aphrodisiac activity. In this study, we evaluated the in vivo aphrodisiac activity of the herbal powder, extract, and the most abundant cyclotide, hyen D, extracted from H. enneaspermus on rats in a single dose regimen. After dosing, the sexual behaviors of male rats were observed, recorded, analyzed, and compared with those of the vehicle group. The results show that the extract and hyen D significantly decreased the intromission latency of sexually naïve male rats and the extract improved a range of other measured sexual parameters. The results suggest that the extract could enhance libido as well as facilitate erectile function in male rats and that the cyclotide hyen D could contribute to the libido-enhancing activity of this ethnomedicinal herb.

Item ID: 71244
Item Type: Article (Research - C1)
ISSN: 1520-6025
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Copyright Information: © 2020 American Chemical Society and American Society of Pharmacognosy.
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The Supporting Information is available free of charge at: https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c01045

Funders: Australian Research Council (ARC)
Projects and Grants: ARC Australian Laureate Fellowship (FL150100146)
Date Deposited: 14 Mar 2022 03:33
FoR Codes: 31 BIOLOGICAL SCIENCES > 3108 Plant biology > 310802 Plant biochemistry @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
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