Immune responses to bacterial lung infections and their implications for vaccination

Muruganandah, Visai, and Kupz, Andreas (2022) Immune responses to bacterial lung infections and their implications for vaccination. International Immunology, 34 (5). pp. 231-248.

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The pulmonary immune system plays a vital role in protecting the delicate structures of gaseous exchange against invasion from bacterial pathogens. With antimicrobial resistance becoming an increasing concern, finding novel strategies to develop vaccines against bacterial lung diseases remains a top priority. In order to do so, a continued expansion of our understanding of the pulmonary immune response is warranted. Whilst some aspects are well characterised, emerging paradigms such as the importance of innate cells and inducible immune structures in mediating protection provide avenues of potential to rethink our approach to vaccine development. In this review, we aim to provide a broad overview of both the innate and adaptive immune mechanisms in place to protect the pulmonary tissue from invading bacterial organisms. We use specific examples from several infection models and human studies to depict the varying functions of the pulmonary immune system that may be manipulated in future vaccine development. Particular emphasis has been placed on emerging themes that are less reviewed and underappreciated in vaccine development studies.

Item ID: 71000
Item Type: Article (Research - C1)
ISSN: 1460-2377
Copyright Information: © The Japanese Society for Immunology. 2021. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record Visai Muruganandah, Andreas Kupz, Immune responses to bacterial lung infections and their implications for vaccination, International Immunology, Volume 34, Issue 5, May 2022, Pages 231–248 is available online at:
Date Deposited: 29 Nov 2021 01:27
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320407 Innate immunity @ 20%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 65%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 35%
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