Survival strategies of intracellular bacterial pathogens

Strugnell, Richard A., Newton, Hayley J., and Kupz, Andreas (2024) Survival strategies of intracellular bacterial pathogens. In: Tang, Yi-Wei, Hindiyeh, Musa, Liu, Dongyou, Sails, Andrew, Spearman, Paul, and Zhang, Jingren, (eds.) Molecular Medical Microbiology. Elsevier, London, United Kingdom, pp. 457-488.

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The common false dichotomy is that bacteria grow either intracellularly or extracellularly, and though there are some bacteria that have an almost viral-like dependency on host cells for metabolites, most can exploit both replicative niches. The facultative intracellular pathogens that preferentially replicate inside cells have evolved mechanisms that defeat or suppress the natural antibacterial cell biology processes associated with endosomal or phagosomal residency, and the nutritional limitations that might be brought about by entrapment within a lipid-bounded vacuole. This chapter describes how bacteria have adapted to intracellular replication and how they use sophisticated protein secretion apparatus and effector molecules, trigger uptake into cells, prevent killing by natural antibacterial processes, subvert host immunity, and replicate to cause some of the most important diseases of humankind, such as tuberculosis and dysentery.

Item ID: 69858
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-12-818619-0
Copyright Information: Copyright © 2024 Elsevier Ltd. All rights reserved.
Funders: NHMRC Investigator Grant
Date Deposited: 10 Nov 2021 03:05
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320407 Innate immunity @ 20%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 65%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 35%
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