Live attenuated vaccines for tuberculosis

Kupz, Andreas (2021) Live attenuated vaccines for tuberculosis. The Biochemist, 43 (4).

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View at Publisher Website: https://doi.org/10.1042/bio_2021_149
 
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Abstract

Tuberculosis (TB) is a leading cause of infectious death worldwide. TB is caused by the bacterium Mycobacterium tuberculosis (Mtb) and transmission happens via inhalation of droplets and aerosols coughed by an individual with active disease. There are about 10 million cases of active TB annually, and it is estimated that approximately 2 billion people are latently infected. Although most latently infected individuals are not sick and do not transmit the disease, in about 5%–10% of these people the disease reactivates. TB kills about 1.5 million people each year and resistance to current treatments increases steadily. Prevention of TB via a vaccine is considered the optimal solution by the World Health Organization. Presently, the only licensed vaccine against TB, Bacillus Calmette-Guérin (BCG), prevents childhood versions of TB but affords low efficiency in the prevention and transmission of the disease in adults. Hence, an improved vaccine is urgently required to combat TB.

Item ID: 69844
Item Type: Article (Scholarly Work)
ISSN: 0954-982X
Copyright Information: © The Authors. Published by Portland Press Limited under the Creative Commons Attribution License 4.0 (CC BY- NC- ND).
Date Deposited: 02 Nov 2021 02:04
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320407 Innate immunity @ 20%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 65%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 35%
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