A Maximum-Likelihood relatedness estimator allowing for negative relatedness values

Konovalov, Dmitry A., and Heg, Dik (2008) A Maximum-Likelihood relatedness estimator allowing for negative relatedness values. Molecular Ecology Resources, 8 (2). pp. 256-263.

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Previously reported maximum-likelihood pairwise relatedness (r) estimator of Thompson and Milligan (M) was extended to allow for negative r estimates under the regression interpretation of r. This was achieved by establishing the equivalency of the likelihoods used in the kinship program and the likelihoods of Thompson. The new maximum-likelihood (ML) estimator was evaluated by Monte Carlo simulations. It was found that the new ML estimator became unbiased significantly faster compared to the original M estimator when the amount of genotype information was increased. The effects of allele frequency estimation errors on the new and existing relatedness estimators were also considered.

Item ID: 6913
Item Type: Article (Research - C1)
ISSN: 1755-0998
Keywords: allele frequency errors; codominant molecular markers; maximum likelihood; relatedness
Date Deposited: 22 Mar 2010 04:24
FoR Codes: 01 MATHEMATICAL SCIENCES > 0104 Statistics > 010401 Applied Statistics @ 50%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) @ 50%
SEO Codes: 89 INFORMATION AND COMMUNICATION SERVICES > 8902 Computer Software and Services > 890299 Computer Software and Services not elsewhere classified @ 100%
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