A Maximum-Likelihood relatedness estimator allowing for negative relatedness values
Konovalov, Dmitry A., and Heg, Dik (2008) A Maximum-Likelihood relatedness estimator allowing for negative relatedness values. Molecular Ecology Resources, 8 (2). pp. 256-263.
![[img]](https://researchonline.jcu.edu.au/style/images/fileicons/application_pdf.png) |
PDF (Published Version)
Restricted to Repository staff only |
Abstract
Previously reported maximum-likelihood pairwise relatedness (r) estimator of Thompson and Milligan (M) was extended to allow for negative r estimates under the regression interpretation of r. This was achieved by establishing the equivalency of the likelihoods used in the kinship program and the likelihoods of Thompson. The new maximum-likelihood (ML) estimator was evaluated by Monte Carlo simulations. It was found that the new ML estimator became unbiased significantly faster compared to the original M estimator when the amount of genotype information was increased. The effects of allele frequency estimation errors on the new and existing relatedness estimators were also considered.
| Item ID: | 6913 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1755-0998 |
| Keywords: | allele frequency errors; codominant molecular markers; maximum likelihood; relatedness |
| Date Deposited: | 22 Mar 2010 04:24 |
| FoR Codes: | 01 MATHEMATICAL SCIENCES > 0104 Statistics > 010401 Applied Statistics @ 50% 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) @ 50% |
| SEO Codes: | 89 INFORMATION AND COMMUNICATION SERVICES > 8902 Computer Software and Services > 890299 Computer Software and Services not elsewhere classified @ 100% |
| Downloads: |
Total: 4 |
| More Statistics |
Actions (Repository Staff Only)
 |
Item Control Page |