Vera, Julio, and Schmitz, Ulf (2013) Computational microRNA Biology. In: Dubitzky, Werner, Wolkenhauer, Olaf, Cho, Kwang-Hyun, and Yokota, Hiroki, (eds.) Encyclopedia of Systems Biology. Springer Nature, New York, NY, USA, pp. 473-480.

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Abstract

MicroRNAs (miRNAs) are small regulatory RNAs of ~22nt length that regulate the activity and stability of a large number of messenger RNAs (Bartel 2004; Ambros 2004; Filipowicz et al. 2008). miRNAs bind to specific messenger RNAs and target them for cleavage, deadenylation, or translational repression. In all three processes, protein synthesis of the targeted messenger RNA is prevented. Until today, a vast amount of human miRNAs has been detected (1.524 human miRNAs are listed in the ▶ miRBase database, r18). Many of them are involved in the regulation of relevant cellular processes, including cell signaling, metabolism, apoptosis, and developmental processes (Ambros 2004).

Item ID:	69005
Item Type:	Book Chapter (Reference)
ISBN:	9781441998637
Copyright Information:	© Springer Science Business Media LLC 2013.
Date Deposited:	19 Dec 2024 01:07
FoR Codes:	31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310201 Bioinformatic methods development @ 50% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310114 Systems biology @ 50%
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