The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions

Schmitz, Ulf, Naderi-Meshkin, Hojjat, Gupta, Shailendra K., Wolkenhauer, Olaf, and Vera, Julio (2016) The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions. Briefings in Bioinformatics, 17 (3). pp. 380-392.

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There was evidence that RNAs are a functionally rich class of molecules not only since the arrival of the next-generation sequencing technology. Non-coding RNAs (ncRNA) could be the key to accelerated diagnosis and enhanced prediction of disease and therapy outcomes as well as the design of advanced therapeutic strategies to overcome yet unsatisfactory approaches.

In this review, we discuss the state of the art in RNA systems biology with focus on the application in the systems biomedicine field. We propose guidelines for analysing the role of microRNAs and long non-coding RNAs in human pathologies. We introduce RNA expression profiling and network approaches for the identification of stable and effective RNomics-based biomarkers, providing insights into the role of ncRNAs in disease regulation. Towards this, we discuss ways to model the dynamics of gene regulatory networks and signalling pathways that involve ncRNAs. We also describe data resources and computational methods for finding putative mechanisms of action of ncRNAs. Finally, we discuss avenues for the computer-aided design of novel RNA-based therapeutics.

Item ID: 68993
Item Type: Article (Research - C1)
ISSN: 1477-4054
Copyright Information: © The Author 2015. Published by Oxford University Press.
Date Deposited: 08 Jun 2022 03:09
FoR Codes: 31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310201 Bioinformatic methods development @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
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