Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy

Ezechukwu, Henry C., Diya, Cornelius A., Egoh, Ifunanya J., Abiodun, Mayowa J., Grace, John-Ugwuanya A., Okoh, God'spower R., Adu, Kayode T., and Adegboye, Oyelola A. (2021) Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy. Therapeutic Advances in Infectious Disease, 8.

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There are a great number of beneficial commensal microorganisms constitutively colonizing the mucosal lining of the lungs. Alterations in the microbiota profile have been associated with several respiratory diseases such as pneumonia and allergies. Lung microbiota dysbiosis might play an important role in the pathogenic mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as elicit other opportunistic infections associated with coronavirus disease 2019 (COVID-19). With its increasing prevalence and morbidity, SARS-CoV-2 infection in pregnant mothers is inevitable. Recent evidence shows that angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) act as an entry receptor and viral spike priming protein, respectively, for SARS-CoV-2 infection. These receptor proteins are highly expressed in the maternal-fetal interface, including the placental trophoblast, suggesting the possibility of maternal–fetal transmission. In this review, we discuss the role of lung microbiota dysbiosis in respiratory diseases, with an emphasis on COVID-19 and the possible implications of SARS-CoV-2 infection on pregnancy outcome and neonatal health.

Item ID: 68778
Item Type: Article (Research - C1)
ISSN: 2049-937X
Keywords: COVID-19, microbiome, microbiota dysbiosis, pregnancy outcome, SARS-CoV-2
Copyright Information: © The Author(s), 2021. article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
Date Deposited: 26 Jul 2021 00:19
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 33%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320402 Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) @ 34%
31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310703 Microbial ecology @ 33%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 100%
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