A small animal model for the creation of pre-aneurysmal change in the intracranial vasculature

Lee, James Anthony (2016) A small animal model for the creation of pre-aneurysmal change in the intracranial vasculature. Masters (Research) thesis, James Cook University.

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View at Publisher Website: https://doi.org/10.25903/QF8T-4G22


Dr James Lee developed a mouse model of early cerebral aneurysm pathogenesis. By exaggerating known risk factors for human aneurysm formation, lesions suggestive of early aneurysmal change were reproduced. This study may be used to further understand human cerebral aneurysm pathogenesis.

Item ID: 67128
Item Type: Thesis (Masters (Research))
Keywords: cerebral aneurysm, elastase, extracellular matrix, hypertension, inflammation, intracranial aneurysms, matrix metalloproteinase, mouse, murine, small animal, stereotactic
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Copyright Information: Copyright © 2016 James Anthony Lee.
Additional Information:

Two publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are:

Wang, Yutang, Emeto, Theophilus I., Lee, James, Marshman, Laurence, Moran, Corey, Seto, Sai-wang, and Golledge, Jonathan (2015) Mouse models of intracranial aneurysm. Brain Pathology, 25. pp. 237-247.

Lee, James A., Marshman, Laurence A.G., Moran, Corey S., Kuma, Leslie, Guazzo, Eric P., Anderson, David S., and Golledge, Jonathan (2016) A small animal model for early cerebral aneurysm pathology. Journal of Clinical Neuroscience, 34. pp. 259-263.

Funders: National Health and Medical Research Council (NHMRC), Medtronic
Projects and Grants: NHMRC 1079193, 1079369, 1021416, 1000967
Date Deposited: 16 Mar 2021 22:56
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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