Genetic control of susceptibility to autoimmune gastritis

Baxter, Alan G., Jordan, Margaret A., Silveira, Pablo A., Wilson, Wendy E., and van Driel, Ian R. (2005) Genetic control of susceptibility to autoimmune gastritis. International Reviews of Immunology, 24 (1-2). pp. 55-62.

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A familial component to the tendency to develop autoimmune gastritis has long been recognized. Although linkage to certain HLA alleles and an association with the endocrine autoimmune diseases thyroiditis and type 1 diabetes have been reported, little further progress has been achieved in clinical studies. In contrast, the mouse model of gastritis induced in the BALB/c strain by thymectomy in the third day of life has identified four linkage regions; two on distal chromosome 4 (Gasa1 and Gasa2), one on chromosome 6 (Gasa3) and one in the H2 (Gasa4). Three of these four genes colocalize with NOD mouse diabetes susceptibility genes—the strongest concordance identified to date between any two autoimmune diseases—reflecting the association between autoimmune diabetes and type 1 gastritis in humans.

Item ID: 6486
Item Type: Article (Research - C1)
ISSN: 1563-5244
Keywords: type A gastritis; diabetes; common gene hypothesis; autoimmune ovarian dysgenesis; risk
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Date Deposited: 23 Mar 2010 05:13
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060199 Biochemistry and Cell Biology not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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