The gut microbiome in psychosis from mice to men: a systematic review of preclinical and clinical studies

Kraeuter, Ann-Katrin, Phillips, Riana, and Sarnyai, Zoltan (2020) The gut microbiome in psychosis from mice to men: a systematic review of preclinical and clinical studies. Frontiers in Psychiatry, 11. 799.

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Abstract

The gut microbiome is rapidly becoming the focus of interest as a possible factor involved in the pathophysiology of neuropsychiatric disorders. Recent understanding of the pathophysiology of schizophrenia emphasizes the role of systemic components, including immune/inflammatory and metabolic processes, which are influenced by and interacting with the gut microbiome. Here we systematically review the current literature on the gut microbiome in schizophrenia-spectrum disorders and in their animal models. We found that the gut microbiome is altered in psychosis compared to healthy controls. Furthermore, we identified potential factors related to psychosis, which may contribute to the gut microbiome alterations. However, further research is needed to establish the disease-specificity and potential causal relationships between changes of the microbiome and disease pathophysiology. This can open up the possibility of. manipulating the gut microbiome for improved symptom control and for the development of novel therapeutic approaches in schizophrenia and related psychotic disorders.

Item ID: 64457
Item Type: Article (Research - C1)
ISSN: 1664-0640
Keywords: gut microbiota, schizophrenia, early life events, inflammation, microbiota metabolites, stress
Copyright Information: Copyright © 2020 Kraeuter, Phillips and Sarnyai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Funders: James Cook University (JCU)
Projects and Grants: JCU Postgraduate Research Grant, JCU Higher Degree Research Enhancement Funding Scheme
Date Deposited: 23 Sep 2020 07:38
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50%
28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50%
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