Protocol for the use of the ketogenic diet in preclinical and clinical practice

Kraeuter, Ann-Katrin, Guest, Paul C., and Sarnyai, Zoltán (2020) Protocol for the use of the ketogenic diet in preclinical and clinical practice. In: Guest, Paul C., (ed.) Clinical and Preclinical Models for Maximizing Healthspan: methods and protocols. Part of the Methods in Molecular Biology book series (MIMB, volume 2138), 2138 . Humana Press, New York, NY, U.S.A, pp. 83-98.

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Many age-related diseases are associated with metabolic abnormalities, and dietary interventions may have some benefit in alleviating symptoms or in delaying disease onset. Here, we review the commonly used best practices involved in applications of the ketogenic diet to facilitate its translation into clinical use. The findings reveal that better education of physicians is essential for applying the optimum diet and monitoring its effects in clinical practice. In addition, investigators should carefully consider potential confounding factors prior to commencing studies involving a ketogenic diet. Most importantly, current studies should improve their reporting on ketone levels as well as on the intake of both macro- and micronutrients. Finally, more detailed studies on the mechanism of action are necessary to help identify potential biomarkers for response prediction and monitoring, and to uncover new drug targets to aid the development of novel treatments.

Item ID: 63655
Item Type: Book Chapter (Research - B1)
ISBN: 978-1-0716-0470-0
Keywords: Age-related disease; Ketogenic diet; Glucose; Insulin; Preclinical studies; Clinical trials; Biomarkers; Novel treatments
Copyright Information: © Springer Science+Business Media, LLC, part of Springer Nature 2020
Date Deposited: 01 Jun 2021 23:54
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 70%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321099 Nutrition and dietetics not elsewhere classified @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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